Pathophysiological role of cation transport and natriuretic factors in hypertension.
نویسندگان
چکیده
This review considers in some detail the hypothetical relationships between sodium fluxes, both active and passive, across the cell membrane, and intracellular sodium concentration in vascular smooth muscle in the animal models of hypertension. It appears that two basic types of transport defects, increased cell membrane permeability to sodium and decreased active pumping of sodium at a given internal sodium concentration, can exist in vascular smooth muscle in experimental hypertension, and that sometimes the two defects coexist, further increasing internal sodium concentration. It is possible that eventually we may find similar transport defects in vascular smooth muscle in humans with arterial hypertension. Decreased active pumping at a given internal sodium concentration appears to result from a humoral sodium pump inhibitor. Future directions for research in the area are also considered. First priority should be given efforts to determine the chemical structure of the sodium pump inhibitor(s). High priority should also be given to attempts to measure passive and active sodium fluxes and intracellular sodium concentration in vascular smooth muscle cells in vivo, and to determine the role of atrial natriuretic factor in the genesis and maintenance of hypertension.
منابع مشابه
Clinical and Biochemical Assessments of Circulating B-Type Natriuretic Peptide as a Useful Marker in Pediatric Cardiac Patients
Background Although the left ventricle is the major site of BNP secretion in response to cardiac pressure or volume overload, the myocytes of both atria and ventricles secrete B- type natriuretic peptide (BNP). This study aimed to assess and compare the plasma levels of BNP in common pediatric cardiac diseases to clarify its pathophysiological role and evaluate its po...
متن کاملAtrial and brain natriuretic peptides in cardiovascular diseases.
The human heart secretes both atrial natriuretic peptide and brain natriuretic peptide. This study attempts to clarify the pathophysiological significance of the peptides in cardiovascular diseases. Using immunoradiometric assay, plasma brain natriuretic peptide and atrial natriuretic peptide levels in essential hypertension, various secondary hypertension, chronic renal failure, chronic heart ...
متن کاملStudy the Transport Properties of Anion and Cation Exchange Membranes toward Various Ions Using Chronopotentiometry
The transport properties of various anion and cation exchange membranes were studied in different electrolyte solutions using chronopotentiometry technique to get insight about the influence of the counter ion on the transport properties of the membranes. The investigated samples include heterogeneous ion exchange membranes varying in the functionality of fixed charged gro...
متن کاملCation Exchange Nanocomposite Membrane Containing Mg(OH)2 Nanoparticles: Characterization and Transport Properties
In this study, ion exchange nanocomposite membranes was prepared by addition of Mg(OH)2 nanoparticles to a blend containing sulfonated polyphenylene oxide and sulfonated polyvinylchloride via a simple casting method. Magnesium hydroxide nanoparticles were synthesized via a facile sono-chemical reaction and were selected as filler additive in fabrication of ion exchange nanocomposite membranes. ...
متن کاملThe Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension.
This review examines the physiological functions of the Li+-Na+ exchanger and Na+-K+-Cl- cotransport system in human red blood cells. Both transporters are family aggregated and determined mainly by genetic factors; they are present in kidney and vascular cells, where they are regulated by vasoactive substances. To assess the physiological function of these two transporters, we investigated the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Hypertension
دوره 10 5 Pt 2 شماره
صفحات -
تاریخ انتشار 1987